The Global/National Missions Work Group of the Presbytery of Charlotte organizes and promotes missions work in the United States and throughout the world:  
The group maintain a partnership with Kenya.  
A mission work trip to Guatemala was successfully completed in mid-July of 2007, as well as another work trip in Costa Rica in October 2007.  
In addition, the group works closely with the Presbytery's Community Disaster Response Team in setting up mission teams to respond to national disasters.